We study how protein intrinsic disorder and post-translational modifications regulate the genome


RESEARCH INTERESTS
Our goal to understand how the eukaryotic genome is packaged with histones into chromatin and how chromatin is propagated, expressed, and those transcripts spliced into mature gene transcripts. 

To improve our basic understanding of biology, human disease, and also to develop new therapeutic approaches, we aim to understand how these processes work and how they are regulated by the cell. Our studies are critically important for understanding diseases such as lung cancer and leukemia, and have wide-ranging implications for human development and neuroscience.  Our current primary research interests are currently in the basic biochemistry, cell biology, and cancer biology of: 

  • Protein Arginine Methyltransferases (PRMTs1-9), their protein substrates, and the "readers" of methylarginine
  • Histone chaperone proteins (NPM1, NPM2, and NAP1) and structural and molecular mechanisms of their intrinsically disordered regions
  • Chaperone post-translational glutamylation and deglutamylation by the TTLL and CCP protein families
NEWS
2020 Check out the new New York City wide chromatinclub: www.nycchromatinclub.org
2020 Joseph DeAngelo (MSTP) joined the lab for his thesis research
2020 Our preprint on PRMTs, methylarginine mass spectrometry, and the proteome and transcriptome is online - link 
2020 Benjamin Lorton publishes a paper in Biochemistry (with the cover image pending!) - link
2020 Christopher Warren publishes a paper in Acta Crystollographica F - link
2020 A new NIH/NIGMS grant (R01GM135614) was awarded to the lab to study histone chaperone glutamylation
. . .
2009 Lab founded

GRANTS
Current:

R01GM108646 NIGMS/NIH “Crosstalk to Histone Arginine Methylation”  (1/2014 - 8/2023)
R01GM135614 NIGMS/NIH “Regulation of Histone Chaperone Function by Glutamylation”  (1/2020-12/2023)
American Lung Association Discovery Award When the Writing Goes Wrong: Protein Arginine Methyltransferases in Lung Cancer” (07/2018-12/2020)
Pilot Funding from Albert Einstein College of Medicine
NIGMS Equipment Supplement to purchase a new AKTA chromatography system

Prior:
Alexandrine and Alexander Sinsheimer Foundation Research Scholar (2011-2014)
American Cancer Society Research Scholar Award (2014-2017)
SAS Foundation for Cancer Research (2018)
NIGMS/NIH Equipment and administrative supplements
Startup funds from Albert Einstein College of Medicine
CONTACT US

Department of Biochemistry 
Albert Einstein College of Medicine 
Forchheimer 304 
1300 Morris Park Avenue 
Bronx, NY 10461  USA