Shechter Lab > Publications

Research papers (since 2010) - Google scholar link

Maxim I Maron, Alyssa D Casill, Varun Gupta, Jacob S Roth, Simone Sidoli, Charles C Query, Matthew J Gamble, David Shechter (2022) Type I and II PRMTs inversely regulate post-transcriptional intron detention through Sm and CHTOP methylation eLife 11:e72867.
Maron MI, Lehman SM, Gayatri S, DeAngelo JD, Hegde S, Lorton BM, Sun Y, Bai DL, Sidoli S, Gupta V, Marunde MR, Bone JR, Sun ZW, Bedford MT, Shabanowitz J, Chen H, Hunt DF, Shechter D. Independent transcriptomic and proteomic regulation by type I and II protein arginine methyltransferases. iScience. 2021 Aug 11;24(9):102971. doi: 10.1016/j.isci.2021.102971.
Christopher Warren, Jeffery B. Bonanno, Steven C. Almo, David Shechter. Structure of a Single Chain H2A/H2B Dimer. Acta Cryst. F 2020
Benjamin M. Lorton, Rajesh K. Harijan, Emmanuel S. Burgos, Jeffrey B. Bonanno, Steven C. Almo, and David Shechter. “A binary arginine methylation switch on histone H3 Arginine 2 regulates its interaction with WDR5. Biochemistry, Jun 2020.
Benjamin Lorton and David Shechter. Cellular consequences of arginine methylation. Cellular and Molecular Life Sciences, Aug 2019.
Wei-Lin Wang, Takashi Onikubo, and David Shechter. Chromatin characterization in Xenopus laevis cell-free egg extracts and embryos. Cold Spring Harbor Protocols, Feb 2019.
Christopher Warren, Tsutomu Matsui, Jerome Karp, Takashi Onikubo, Sean Cahill, Michael Brenowitz, David Cowburn, Mark Girvin, and David Shechter. Dynamic intramolecular regulation of the histone chaperone nucleoplasmin controls histone binding and release. Nature Communications, 2017
Emmanuel S. Burgos, Ryan O. Walters, Derek M. Huffman and David Shechter. A simplified characterization of S-adenosyl-L-methionine-consuming enzymes with 1-Step EZ-MTase: a universal and straightforward coupled-assay for in vitro and in vivo setting. Chem. Sci., 2017
Christopher Warren and David Shechter. Fly Fishing for Histones: Catch and Release by Histone Chaperone Intrinsically Disordered Regions and Acidic Stretches. J Mol Biol. 2017 doi:10.1016/j.jmb.2017.06.005
Wei-lin Wang and David Shechter. Chromatin assembly and transcriptional cross-talk in Xenopus laevis oocyte and egg extracts. Int J. Dev. Biol. 2016. doi: 10.1387/ijdb.160161ds
Hongshan Chen, Benjamin Lorton, Varun Gupta, and David Shechter. A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression. Oncogene, Jun 2016.
Takashi Onikubo, Joshua J. Nicklay, Li Xing, Christopher Warren, Brandon Anson, Wei-Lin Wang, Emmanuel S. Burgos, Sophie E. Ruff, Jeffrey Shabanowitz, R. Holland Cheng, Donald F. Hunt, and David Shechter. Developmentally Regulated Post-Translational Modification of Nucleoplasmin Controls Histone Sequestration and Deposition. Cell Reports, Mar 11 2015; doi:10.1016/j.celrep.2015.02.038
Histone H2A and H4 N-Terminal Tails are Positioned by the MEP50 WD-Repeat Protein for Efficient Methylation by the PRMT5 Arginine Methyltransferase. Emmanuel S. Burgos, Carola Wilczek, Takashi Onikubo, Jeffrey B. Bonanno, Janina Jansong, Ulf Reimer and David Shechter. Journal of Biological Chemistry, 2015.
The PRMT5 arginine methyltransferase: many roles in development, cancer, and beyond. Nicole Stopa, Jocelyn Krebs, David Shechter. Cellular and Molecular Life Sciences, 2015.
Phosphorylation and arginine methylation mark histone H2A prior to deposition during Xenopus laevis development
Wei-Lin Wang, Lissa C Anderson, Joshua J Nicklay, Hongshan Chen, Matthew J Gamble, Jeffrey Shabanowitz, Donald F Hunt and David Shechter. Epigenetics & Chromatin, 2014. 7:22
Structure of the Arginine Methyltransferase PRMT5-MEP50 Reveals a Mechanism for Substrate Specificity Ho MC, Wilczek C, Bonanno JB, Xing L, Seznec J, Matsui T, Carter LG, Onikubo T, Kumar PR, Chan MK, Brenowitz M, Cheng RH, Reimer U, Almo SC, Shechter D.(2013).PLoS ONE 8(2): e57008. doi:10.1371/journal.pone.0057008.
Protein Arginine Methyltransferase Prmt5-Mep50 Methylates Histones H2A and H4 and the Histone Chaperone Nucleoplasmin in Xenopus laevis Eggs. Wilczek C, Chitta R, Woo E, Shabanowitz J, Chait BT, Hunt DF, Shechter D.. J Biol Chem. 2011 Dec 9;286(49):42221-31.
Laura Banszynski, C. David Allis, David Shechter. Analysis of histones and chromatin in Xenopus laevis egg and ooctye extracts. Methods. 2010. Vol 51:1.

Reviews and book chapters (since 2010)

David Shechter. 2014. “Seeing Beyond the Double Helix.” Journal of Pediatric Ophthalmology & Strabismus. Vol. 51, No. 5.
Nicole Stopa, Jocelyn Krebs, David Shechter. 2015. “The PRMT5 Arginine Methyltransferase: Many Roles in Development, Cancer, and Beyond.” Cellular and Molecular Life Sciences, Feb 7. (11):2041-59. PMID: 25662273 PMCID: PMC4430368
Takashi Onikubo and David Shechter. 2016. “Chaperone-mediated chromatin assembly and transcriptional regulation in Xenopus laevis.” Int J. Dev. Biol. doi: 10.1387/ijdb.130188ds
Christopher Warren and David Shechter, 2017. “Fly Fishing for Histones: Catch and Release by Histone Chaperone Intrinsically Disordered Regions and Acidic Patches”, J. Mol Biol 429(16):2401-2426. doi: 10.1016/j.jmb.2017.06.005. PMID: 28610839 PMCID: PMC5544577 *
Benjamin Lorton and David Shechter. 2019. “Cellular Consequences of Arginine Methylation” Cell. Mol. Life Sci. 76, 2933–2956 (2019). https://doi.org/10.1007/s00018-019-03140-2